The journal of high-impact "Oncotarget" published the results of the research project of Dr. Masetti

The journal of high-impact

It is with great satisfaction that Fondazione Ginevra Caltagirone learns of publication in the journal of high-impact "ONCOTARGET" results of the continuation of the Research Project on the characterization of myeloid leukemia in early childhood by means of Next Generation Sequencing.
The studies carried out with economic contribution of Fondazione Ginevra Caltagirone have produced the discovery of a first reading of the fusion transcript DHH-RHEBL1 reported in a specific subgroup
of pediatric leukemia.
In summary, it was discovered a novel DHH-RHEBL1 fusion transcript that is recurrent (40%) in CBFA2T3-GLIS2-positive patients only; it characterizes a subset of patients with an even more dismal outcome among the CBFA2T3-GLIS2-positive patients.
The mechanism(s) through which this fusion transcript promotes leukemogenesis and the possibility of targeting it with pathway-specific compounds remain to be thoroughly investigated.